Silicon nanomaterials in diagnostics

Photonic biosensors

  • Ultrasensitive
  • Cheap/mobile
  • Quantitative
  • Naked eye readout
  • Best for proteins, enzymes and DNA oligos

     

 

 

 

 

 

Advanced Functional Materials, 24 (2014), 3639-3650; ACS Sensors, 2 (2017), 203-209.

 

Laser desorption/ionisation mass spectrometry

  • High throughput
  • Multi-analyte
  • Analysis of body fluid 
  • Illicit drugs, metabolites

 

 

 

 

 

Chemical Communications, 51 (2015), 6088 – 6091; Scientific Reports, 9 (2019), 12342.      

 

Theranostic systems

  • Combined stimulus-responsive polymers
  • Detection of pH, temperature, glucose
  • Naked eye readout
  • Integration into wound dressings
  • Focus on chronic wounds

 

 

 

 

 

 

Langmuir, 32 (2016), 301-308; ACS Applied Bio Materials, 2 (2019) 704-716.      

 

Electrochemical biosensors

  • Nanochannel & nanoneedle architectures
  • Ultrasensitive
  • Work in complex media
  • Current focus is on hormone, endotoxin, virus detection

 

 

 

 

 

 

 

Advanced Functional Materials, 2019, 1809206; ACS Sensors, 4 (2019), 1515-1523.