Silicon nanomaterials in drug delivery

Cell targeting porous nanoparticles

  • Antibody display on outside
  • Loaded with anti-cancer or immunosuppressive drug
  • Biodegradable/biocompatible
  • Co-loading with siRNA
  • Multistage delivery vector

Advanced Functional Materials, 25 (2015), 7215–7225.;

ACS Nano, 12 (2018), 6637-6647.

 

Drug delivery on demand

  • Gold nanoparticles and clusters
  • Applications in cancer and chronic wounds
  • Microwave-induced hyperthermia
  • Responsive drug delivery
  • Antibiotic delivery
  • Reversible display of ligands

Nature Communication, 6 (2015), 8791;

Small, 13 (2017), 1701201.

 

Therapeutic antibody delivery

  • Packaged in porous silicon nanoparticles
  • High payload
  • Controlled release
  • Focus on chronic wounds/ocular disease
  • Protects antibody from degradation

Advanced Healthcare Materials, 6 (2017), 1600707.

 

Gene delivery via nanowire arrays

  • Nanofabrication
  • High-efficiency gene transfection
  • Vaccine delivery

Advanced Functional Materials, 25 (2015), 1137-1145;

Small, 15 (2019), 1904819.